2. 您的位置
3. 首页
4. 会议论文
5. Presynaptic cyclic GMP-dependent protein kinase I in nociceptors is a key determinant of spinal syna

Presynaptic cyclic GMP-dependent protein kinase I in nociceptors is a key determinant of spinal syna

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：long5139

【摘 要】

：

Chronic pain represents a major challenge to clinical practice and basic science.Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery

【作 者】

：

Luo C Gangadharan V Xie RG Liu DL Hu SJ Kuner R 

【机 构】

：

Institute of Neuroscience, Fourth Military Medical University, 17 West Chang-le Road,710032 Xi'an,

【出 处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年9期

【关键词】

：

Presynaptic PKG-I spinal LTP pain hypersensitivity 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Chronic pain represents a major challenge to clinical practice and basic science.Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.

其他文献

A New Generation Cancer Diagnostic Technology with High Sensitivity and Specificity, Fast Detection

Purpose: Existing cancer diagnosis technologies offer some degree of effectiveness but in general, they lack ability to detect cancer at an early stage, have low sensitivity and specificity for certai

会议

A Novel Camptothecin Derivate-ZBH-ZM-06 Revealed Potent Antitumor Activities Than CPT-11 And SN38

Purpose: The aim of this study is to characterize the antitumor activity of a novel camptothecin derivate ZBH-ZM-06 and compare with other Topo-1 inhibitors CTP-11 and SN38.Methods: MTT assay was empl

会议

HBME-1、Galectin-3及34βE12在甲状腺微小乳头状癌中的鉴别诊断价值

目的 回顾性分析甲状腺微小乳头状癌(PTMC)和甲状腺良性结节中HB ME-1、Galectin-3及34βE12的表达差异，并探讨其鉴别诊断的临床价值。方法 采用免疫组化方法检测并比较189个PTMC病灶及106例甲状腺良性结节中HBME-1、Galectin-3及34β E12的表达水平，计算其对PTMC的诊断效能指标。

会议

人非小细胞肺癌原位动物模型的构建及生物学特性比较研究

目的：采用不同方法建立人非小细胞肺癌原位动物模型，比较研究不同方法建立的人非小细胞肺癌原位动物模型生物学特性，筛选有效、稳定的人非小细胞肺癌原位动物模型方法，探讨不同方法建立人非小细胞肺癌原位动物模型的效果。方法：分别采用经胸壁穿刺、经气管穿刺两种方法，将人非小细胞肺癌H460SM细胞接种于SCID小鼠和辐射后的裸大鼠左肺内，构建人非小细胞肺癌原位动物模型，并与SCID小鼠皮下移植瘤模型比较，观察

会议

肺肿瘤原位动物模型转移

The mechanisms and functions of ATP-induced P2X3 receptor trafficking in primary sensory neurons

The purinergic (P)2X3 receptor, an ATP-gated ion channel, plays a vital role in sensory processing and transmission.The assembly and trafficking of P2X3 receptor are important for its function in prim

会议

P2X3 receptorATPreceptor traffickingprimary sensory neuron

Facilitated corticospinal projecting neurons after peripheral nerve injury

Long term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain.In case of persistent chronic pain, peripheral injury triggered LTP in the spinal co

会议

LTPanterior cingulate cortexGluA1pain

Is Acid Painful?

Acid (or proton) is an effective algogen to excite nociceptors and evoke pain.Is acid really painful? For patients who suffer with arthritis, fibromyalgia, myofascial pain, etc., the answer is definit

会议

Adrenergic z-receptor mediates itch hypersensitivity following heterotypic chronic stress in rats

Chronic stress is widely considered to trigger or enhance itch, especially for pruritic dermatitis.However, the molecular mechanisms linking chronic stress and itch are still unknown.The present study

会议

Chronic stressItchSympathetic nervous systemAdrenergic receptors

Differential roles of parabrachial nucleus in pain and itch

Spinal cord projection neurons mainly target the parabrachial nucleus, which could be important in pain and itch signal processing.However, the synaptic property and functional role of this projection

会议

Taming serotonin outflow and inflammatory colonic hyperalgesia by blocking Ih channels in enterochro

Treatment of Crohns disease (CD) and ulcerative colitis (UC), collectively known as inflammatory bowel diseases (IBD), has been a major clinical challenge, whereas the incidence of IBD has been on the

会议