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BackgroundDistractionosteogenesis(DO)successfullyinduceslarge-sizebonedefectregeneration,butitinvolvesundesirably longdurationoftreatment.Developinginnovativeapproachestoaugmentboneconsolidationisinburningneed.Staphylococcal Enterotoxin C2(SEC2) has been developed and found to promote osteogenesis and suppress osteoclastogenesis of human mesenchymalstemcellinvitro.Inthisstudy,weinvestigatedwhetherSEC2couldaccelerateboneconsolidationinaDOrat model.