An Aptamer-Conjugated Liposomal System Containing a Bubble-Generating Agent for Tumor-Specific Chemo

来源 :纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会 | 被引量 : 0次 | 上传用户：wuaiboer

【摘要】

：

【作者】

：

Wei-Lin Wan Zi-Xian Liao Er-Yuan Chuang Chia-Chen Lin Hsing-Wen Sung

【机构】

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Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua Unive

【出处】

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纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会

【发表日期】

：

2015年11期

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　　Recent research in chemotherapy has prioritized overcoming the multidrug resistance (MDR) of cancer cells.In this work, liposomes that contain doxorubicin (DOX) and ammonium bicarbonate (ABC, a bubble-generating agent) are prepared and functionalized with an antinucleolin aptamer (AS1411 liposomes) to target DOX-resistant breast cancer cells (MCF-7/ADR), which overexpress nucleolin receptors.

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An Aptamer-Conjugated Liposomal System Containing a Bubble-Generating Agent for Tumor-Specific Chemo

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