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Objective Obstructive sleep apnea (OSA) can cause cognitive dysfunction.Exposure to intermittent hypoxia, such as an important pathophysiological mechanism in OSA-related damage, is always marked by nervous system injury in rat brain.In this study, we established a rat intermittent hypoxia model to observe the effect on iNOS expression in the hippocampus induced by intermittent hypoxia and to explore the potential mechanism.