AZ/AZIN调控对A549非小细胞肺癌细胞作用研究

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：jioowewi

【摘要】

：

肿瘤的快速生长高度依赖于多胺，使得多胺的代谢途径成为抗肿瘤治疗研究的新靶点，特别是以鸟氨酸脱羧酶(ODC)为核心，鸟氨酸脱羧酶抗酶(AZ)和鸟氨酸脱羧酶抗酶抑制因子(AZIN)共同调节的调控网络。基于现有的针对于ODC抑制的抑制剂临床应用弊端，本课题拟探索以AZ/AZIN通路作为抗肿瘤治疗分子靶点的潜在价值。

【作者】

：

欧洁王顺超吴红艳

【机构】

：

三峡大学医学院感染与验证损伤研究所,湖北宜昌443002 三峡大学肿瘤微环境与免疫治疗湖北省重点

【出处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

人非小细胞肺癌A549细胞鸟氨酸脱羧酶鸟氨酸脱羧酶抗酶鸟氨酸脱羧酶抗酶抑制因子

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AZ/AZIN调控对A549非小细胞肺癌细胞作用研究

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