【摘 要】
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Cancer treatment still faces a lot of obstacles such as tumor heterogeneity,drug resistance and systemic toxicities.Beyond the traditional treatment modalities,exploitation of RNA interference(RNAi)as
【机 构】
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State Key Laboratory of Ophthalmology,Optometry and Vision Science,Wenzhou Medical University,Wenzho
【出 处】
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2018中西部地区无机化学化工学术研讨会
论文部分内容阅读
Cancer treatment still faces a lot of obstacles such as tumor heterogeneity,drug resistance and systemic toxicities.Beyond the traditional treatment modalities,exploitation of RNA interference(RNAi)as an emerging approach has immense potential for treatment various gene-caused diseases including cancer.The last decade has witnessed enormous research and achievements focused on RNAi biotechnology.However,delivery of small interference RNA(siRNA)remains a key challenge in the development of clinical RNAi therapeutics.Indeed,nanomaterials-formulated siRNA systems have potential applications for protection of siRNA from degradation,improving the accumulation in the target tissues,enhancing the siRNA therapy and reducing the side effects.Here,we explore and summarize the role of functional inorganic-organic hybrid systems involved in the siRNA therapeutics advancements.Inorganic-organic hybrid platforms as the vectors for siRNA delivery are promising to give credit to the interdisciplinary cooperation between inorganic,organic,biology and medicine.
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