BAP1 promotes triple-negative breast cancer partially by deubiquitinating KLF5

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户：youling0186

【摘要】

：

　　The transcription factor KLF5 is highly expressed in basal triple-negative breast cancer (TNBC) and promotes breast cancer cell proliferation, survival and

【作者】

：

Junying Qin Ceshi Chen

【机构】

：

Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunn

【出处】

：

中国细胞生物学学会2015年全国学术大会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The transcription factor KLF5 is highly expressed in basal triple-negative breast cancer (TNBC) and promotes breast cancer cell proliferation, survival and tumor growth.However, the mechanism by which KLF5 is regulated in breast cancer remains unclear.

其他文献

Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activatio

　　Histone methylation status in different lysine residues has an important role in transcription regulation.The effect of H4K20 monomethylation (H4K20mel) on

会议

A novel role of PGC-1α in cell cycle regulation

　　Peroxisome proliferator-activated receptor-γ coactivator 1-α(PGC 1 α) is a transcriptional coactivator able to up-regulate mitochondrial biogenesis, resp

会议

CHL1 regulates glioma cell proliferation and survival in vitro and in vivo

　　The cell adhesion molecule with homology to L1CAM (close homolog of L1) (CHL1) is a member of the cell adhesion molecule L1 (L1CAM) gene family.Althogh L1CA

会议

rBTI通过诱导ROS的短暂升高延长秀丽隐杆线虫的寿命

　　在过去的几十年中,秀丽隐杆线虫(Caenorhabditis elegans,C.elegans)因为其众多的优点已经成为研究抗衰老及抗衰老药物的经典模型,目前已经发现多种天然物质能够延长秀丽

会议

诱导ROS升高秀丽隐杆线虫抗衰老作用trypsin inhibitor胰蛋白酶抑制剂抗衰老药物

LIMK1/SSH-1L介导的信号网络调控人成骨肉瘤多药耐药细胞的机制

　　目的诱导并建立耐长春新碱(VCR)的入骨肉瘤细胞株并探讨其耐药机制。方法采用逐步增加药物剂量冲击诱导方法诱导人成骨肉瘤MG63细胞株；CCK-8法检测亲本与耐药细胞株对VC

会议

介导信号网络调控人成骨肉瘤多药耐药细胞多药耐药相关蛋白多药耐药基因诱导方法

Notch signaling induced Endothelial mesenchymal transition contribute to unilateral ureteral obstruc

　　Renal fibrosis is the final outcome of all progressive kinds of chronic kidney disease.The aim to explore the mechanism and block the progress of renal fibr

会议

KIF11作为一个新的caspase-1靶点嵌合到caspase-1依赖性的细胞死亡

　　细胞驱动蛋白KIF11能在有丝分裂时期将中心粒分离。抑制KIF11可激活caspase-3而引起细胞凋亡，但其信号通路相关机制尚未知晓。为了弄清这一细胞死亡通路，我们以人胚肾细胞H

会议

caspase-1靶点嵌合依赖性细胞死亡脂质体转染人胚肾细胞MDA-MB-231

Inhibition of Humanized Antibody cHAb18 On Hepatocellular Carcinoma Cell Motility and Involving Mole

　　CD147 is highly expressed in tumor tissues and on the membrane of tumor cells.Our previous studies have proved that the interaction of CD147 with integrin c

会议

Purinergic Signaling Regulates Sperm Chemotaxis Induced by Uterus-derived Factor (UDF) in Nematode A

　　Directional migration of sperm to oocyte is the prerequisite for successful fertilization.In most animal species, motile sperm are attracted by chemical fac

会议

Selected inhibition by herbicide acetochlor of adrenergic receptor mediated calcium oscillations in

　　Herbicide acetochlor after application enters both surface and underground waters, so that the equilibrated acetochlor concentrations in rivers and streams

会议

BAP1 promotes triple-negative breast cancer partially by deubiquitinating KLF5

与本文相关的学术论文