基于LC-MS/MS代谢组学技术的食管癌潜在诊断标志物研究

来源 :2018年中国质谱学术大会 | 被引量 : 0次 | 上传用户：yjddstevens

【摘要】

：

最新统计显示,食管癌在世界范围肿瘤发病率中位居第六、致死率居第七,其中每年约有50％的新病例发生在中国1.我国食管癌患者以食管鳞癌(ESCC)为主,早期食管癌患者无明显症状,多数患者在确诊时已处于疾病中晚期,其5 年生存率不足20％2,因此开展与食管癌早期诊断相关的研究具有重要意义.

【作者】

：

李江硕徐婧张瑞萍陈艳华贺玖明再帕尔·阿不力孜

【机构】

：

中国医学科学院/北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050

【出处】

：

2018年中国质谱学术大会

【发表日期】

：

2018年7期

【关键词】

：

食管癌代谢组学 LC-MS/MS技术生物标志物

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

The Catalytic 4-Nitrophenol Reduction with Protein-Gold Hybrid Nanoparticles by the Conductive Polym

The conductive polymer(CP)as the spray substrate was employed to study the catalysis mechanism of protein-Au hybrid nanoparticles(NPs)to the reduction reaction of 4-nitrophenol.

会议

Nitro-reduction reactionProtein-Au hybrid nanoparticlesReaction intermediates

Improved peptide identification in shotgun proteomics data using an efficient open search engine

Shotgun proteomics has grown rapidly in recent decades,especially for peptide and protein identification.

会议

Mass SpectrometrypFinddatabase searchmodification

Comprehensive evaluation of untargeted metabolomics data processing software in feature detection,qu

Data analysis represents a key challenge for untargeted metabolomics studies and it commonly requires extensive processing of more than thousands of metabolite peaks included in raw high-resolution MS

会议

Untargeted metabolomicsData processing softwareFeature detectionFeature quant

Imaging and ex-vivo tissue analysis by Infrared CO2 Laser Assisted Rapid Evaporative Ionisation MS -

As a direct combination of surgical diathermy and MS analysis of the electrosurgical aerosol,rapid evaporative ionization mass spectrometry(REIMS)is a novel ambient ionization method.

会议

rapid evaporative ionization mass spectrometry (REIMS)iknifeMS imagingCO2 las

基于质谱的靶向蛋白质组学联合分子印迹同时定量测定Cyt c-HSP27和Cyt c-Bcl-xL蛋白质相互作用

细胞色素c(Cyt c)在细胞凋亡中发挥着重要作用。然而,它的功能在乳腺癌发生发展中往往会受到与其相互作用的蛋白质(Protein-Protein Interaction,PPI)的影响。在这些相互作用的蛋白质中,HSP27 和BclxL是Cyt c 的重要负性调节蛋白,能够抑制Cyt c 的释放、阻碍凋亡小体的生成。

会议

基于质谱的靶向蛋白质组学分子印迹多种蛋白质相互作用同时定量测定Cytc-HSP27Cytc-Bcl-xL

A New Reagent for One-Step Derivatization and Enrichment of Protein Post-Translational Modifications

Post-translational modifications(PTMs)of proteins play fundamental roles in controlling almost every aspect of protein functions.

会议

Post-translational modificationsO-GlcNAcEnrichmentMass spectrometryWestern-b

MS/MSALL Strategy for Comprehensive Lipidomics

The lipidome of biological samples is comprised of thousands of lipid molecular species.

会议

mass spectrometryshotgun lipidomicsMS/MSALLqTOF

NAD Proteome and Metabolome in Aging and Its Associated Diseases

Nicotinamide adenine dinucleotide(NAD)is essential to human life,which participates in multiple cellular processes for maintaining energy homeostasis,metabolic homeostasis and redox homeostasis,and fo

会议

NADProteomeMetabolomeAgingTumor

光化学衍生质谱分析斑马鱼胚胎不饱和脂质异构体

斑马鱼(Danio rerio)是发育生物学研究中常用的模式脊椎动物，其基因组和人类具有较高的相似性。斑马鱼胚胎在体外发育，发育周期短，体积较大且通体透明，便于进行各类发育生物学研究。

会议

不饱和脂质斑马鱼胚胎发育Paterno-Buchi反应串联质谱

The study of drug resistance mechanisms of breast cancer cells by quantitative mass spectrometry

The SHC1 adaptor protein directly binds to all members of the HER/ERBB receptor tyrosine kinase family and forms a critical link between the receptors and downstream effectors1,2.

会议

Quantitative mass spectrometryDrug resistanceDynamic SignalingBreast cancer c

基于LC-MS/MS代谢组学技术的食管癌潜在诊断标志物研究

与本文相关的学术论文