论文部分内容阅读
Despite decades of research and drug development for cancer treatment, cancer still remains one of the major causes of human deaths in the world.Human cancers consist of a mixed popuhtion of malignant cells that carry multiple genetic mutations.Many of them are driver mutations that determine tumor initiation, progression, and metastasis.The genomic landscapes indicate that multiple signal transduction pathways determine the fate of a cancer cell, and it is almost impossible to treat cancer with a single therapeutic agent.