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儿童期肿瘤INCIDENCE CHILDHOOD CANCER (Globally)Childhood 160,000 new cases/year ＜ 15 years of age 90,000 deaths/year ＜ 15 years of age 肿瘤类型白血病脑瘤淋巴瘤神经母细胞瘤肾母细胞瘤软组织肉瘤骨肉瘤尤文氏肉瘤……发病原因CAUSES OF CHILDHOOD CANCERS Identified familial and genetic factors (5-15％) 2.Known Environmental exposures & exogenous factors (＜5-10％)3.UNKNOWN 75-90％基因组变异与人类疾病染色体异常拷贝数变异单基因变异染色体病基因组病单基因疾病多基因疾病线粒体基因病体细胞遗传病肿瘤基因组计划