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Aim To study the antihypertensive effect of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats, then preliminarily investigate the mechanism of action based on antiinflammatory function.Methods Total flavonoids of COM (COMF) were separated and purified by the optimal process, SHR were divided into 6 groups as SHR control group (SHR), captopril group (CAP, 25rg · kg1 · d1), Eucommia ulmoides Oliver group (EUO, 30 mg · kg1 · d1), low (COMFL, 40 mg · kg1 · d1), middle (COMFM, 80 mg ·kg1 · d1) and high dose (COMFH, 160 mg · kg1 · d1) of COMF groups.8 WistarKyoto (WKY) rats were given distilled water instead as control.The drugs were given by intragastric administration for 16 weeks, then the levels of IL1β, IL6, IL10, TNFα and CRP in serum were tested.Results Compared with WKY group, the levels of IL1β, IL6, TNFα and CRP were increased and IL10 was decreased; Compared with SHR group, the levels of IL1 β, IL6, TNFc and CRP were decreased in COMF groups (P <0.01 or P <0.05), while IL10 was increased a little but without any significant difference (P < 0.05).Conclusion Total flavonoids of Cydonia oblonga Mill.showed the antihypertensive activity in spontaneously hypertensive rats and the mechanism was related to the function of antiinflammatory.