The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic vohammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode.A simple and sensitive differential pulse voltarnmetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time.The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated.Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of 8.95 × 10-s M ～ 5.29 × 10-5 M, with a relatively low detection limit of 4.42 × 10-s M.