Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric ca

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户:hpp6855132
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Inactivation of tumour suppressor genes by promoter methylation plays an importaatrole in the initiation and progression of gastric cancer (GC).The identication of novel promoterhypermethylated genes may provide insights into the mechanisms of inactivation oftumor suppressive pathways and identify tumor markers for GC.
其他文献
Recombinant derived proteins are becoming increasingly important as therapeutic agents.HMGB1, composed of the A box, B box and C tail domains, is a critical proinflammatory cytokineinvolved in diverse
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine.In addition toits known receptor-mediated biological activities,MIF possesses a catalytic site of unknownfunction between sub
Background/Aims:Sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P)/S 1P.receptor (S1PR) axis is involved in multiple biological processes,including liver fibrosis.
The canonical Wnt/β-catenin pathway plays an important role in hair cycle induction.Wnt5a is a non-canonical Wnt family member that generally antagonizes canonical Wnt signaling in other systems.
Background Previous studies suggest Hedgehog signaling is essential for gastric cancer,but the precise function of Hedgehog signaling in gastric cancer is still unclear.The aim of this study is to cla
Chemotaxis is a phenomenon that motile bacteria move directionally alone chemicalgradients in the environment.This ability depends on the chemoreceptors which can deteetminute concentration changes in
This study is to observe the protecting effects of melatonin on the hemoglobin re-releasedfrom hydrogen peroxide (H2O2) damaged red blood cells (RBCs).Firstly, RBCs weretreated with 0.25%, 0.5%, 1%, 2
Directed molecular evolution of enzymes in vitro is a crucial strategy for understanding thenature enzyme evolution and creating the novel biocatalysts which could meet the requirementsin industrial p
Enzyme promiscuity can function as a starting point in divergent evolution for generatinga specific enzyme in the presence of selective stress.A better understanding of catalyticpromiscuity can improv
Ribosome formation in eukaryotes requires a large number of transiently associated assemblyfactors that coordinate processing and folding of pre-rRNA and binding of ribosomalproteins.Krr1 and Faf1 are