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Background To evaluate the feasibility of real-time myocardial contrast echocardiography performing on models of myocardial ischemic-reperfusion rabbits,and to observe the effects of ischemic postconditioning on myocardial no-reflow.Methods Totally 60 New Zealandwhite rabbits were randomly divided into Sham operation (sham) group,ischemia reperfusion (IR) group and ischemic postconditioning (IPostC) group,with 20 rabbits in each group.Sham group: only thoracotomy without ligation,and suctures were inserted under the left anterior descending artery (LAD);IR group: LAD occlusion for lh and reperfuseion for 2h;IPostC group: four episodes of 30s reperfusion and 30s occlusion after lh ischemia,and before 2 hours of reperfusion.ECG monitoring was continuously performed during operation.