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Plasmids expressing macrophage migration inhibitory factor (MIF) of Trichinella spiralis (TsMIF),multi-cystatin-like domain protein (MCD-1) of T.spiralis (TsMCD-1),or co-expressing TsMIF and TsMCD-1 were constructed with a pVAX1 vector.Their ability to generate a protective immune response against T.spiralis infection was evaluated in BALB/c mice.Groups of mice were immunized twice at 2-week intervals with 100 mg of recombinant plasmids pVAX1-Tsmif,pVAX1-Tsmcd-1 or pVAX 1-Tsmif-Tsmcd-1.