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Our group has focused on the fact that psoriasis has a very high heritability index; over 80% of the elements that lead to psoriasis and its associated disorders have a genetic basis.This coupled with the fact that psoriasis presents as a disorder of protean manifestations has made it increasingly apparent that psoriasis is a complex multigenic disorder,i.e.,there are multiple genes that interact epistatically in the processes that lead to the clinical manifestations of psoriasis and perhaps to responses to treatment.