1H Magnetic Resonance Spectroscopic Imaging Detection of Elevated Total Creatine as a Potential Biom

来源 :BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会) | 被引量 : 0次 | 上传用户:sunjava2009
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Introduction: For over two decades, levels of major brain metabolites, such as N-acetylaspartate (NAA) and total choline (tCho), detected in vivo by proton magnetic resonance spectroscopy (1 H MRS) have routinely been reported as ratios relative to the creatine (Cr) + phosphocreatine (PCr) resonance-i.e, total creatine or tCr-under the assumption that its spectral intensity remains constant as a result of the creatine phosphokinase-catalyzed interconversion of Cr and PCr.Here, we report three clear-cut cases of MRS detection of dramatic elevations oftCr in brain tumors, which both suggests the potential utility of tCr as a brain cancer biomarker, and adds incontrovertible evidence to the growing body of literature data that has challenged the validity of the assumption that the integrated peak area of total brain creatine is constant, making it suitable for use as an internal concentration reference against which to assess changes in the other metabolites.
其他文献
Colorectal cancer (CRC) is one of the commonest cancers wordwide.The risk factors for CRC are both environmental and genetic.Approximately 75% of CRCs are sporadic; the rest are hereditary or belong t
会议
Current immunomagnetic enrichment (IE) method can only detect general epithelial antigens of circulating tumor cells (CTCs).Further characterization of the CTCs to provide specific information on the
会议
Neoadjuvant chemoradiation followed by surgery is standard of care for locally advanced rectal cancer.The impact of pathologic response remains unclear.We reviewed the impact of pathologic response on
会议
Hereditary colorectal cancer syndromes are classified according to the presence of unusually large number of adenomatous or hamartomatous polyps, or their absence.The latter category includes.Lynch sy
会议
A Systematic Review: Non-entry of eligible patients into surgical randomised control trials (RCTs) is the most significant barrier to their success of & the most serious threat to the validity of thei
会议
First line therapy in the treatment of gliomas and malignant melanomas are alkylating agents.These agents induce a dozen of different DNA damages, some of them have been identified to be carcinogenic,
会议
Activation of urokinase-type plasminogen activator (uPA) receptor (uPAR) has been implicated in the initiation of proteolytic, adhesion and signal transduction mechanisms that permit metastasis by col
会议
The usefulness of targeting individual genetic mutations in cancer is limited by the huge variety of cancer genotypes.In contrast, the phenotypes of nearly all solid tumors include a high rate of lact
会议
Serial tomotherapy is a technique that allows slice by slice treatment of intracranial targets using an intensity modulated radio therapeutic algorithm and a Linear Accelerator.In the last 2 years we
会议
Malignant gliomas are resistant to many kinds of treatments including chemotherapy, radiotherapy, and other adjuvant therapies.Autophagy is a novel response of cancer cells to ionizing radiation (IR)
会议