【摘 要】
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The development of biodegradable cationic polymers for gene delivery is desirable to circumvent the drawbacks of the viral vectors [1].Additionally,degradable polymers have the potential to overcome c
【机 构】
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BK21 PLUS Center for Advanced Chemical Technology,Department of Polymer Science and Engineering,Pusa
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
The development of biodegradable cationic polymers for gene delivery is desirable to circumvent the drawbacks of the viral vectors [1].Additionally,degradable polymers have the potential to overcome cellular toxicities that are related to the high charge densities of the polycationic delivery system [2].Therefore,to produce a biocompatible delivery vehicle,we have designed novel biodegradable triblock copolymers consisting of repeating units of poly(ethylene glycol) methyl ether acrylate (PEGA) conjugated to cationic poly(L-lysine) (p(Lys)) and poly(L-histidine) (p(His)) with different chain lengths [p(PEGA)30-b-p(Lys)100-b-p(His)n] (n =25,50,75,100) via the combination of reversible addition fragmentation transfer polymerization,ring opening polymerization of α-amino acid N-carboxyanhydrides and click cycloaddition reactions.
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