【摘 要】
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The importance of molecular diversity has been clearly recognized to identify specific bioactive small molecules for the elucidation of mysterious biological pr
【机 构】
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DepartmentofChemistry,SeoulNationalUniversity,Seou1151-747,Korea
【出 处】
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The 24th International Society of Heterocyclic Chemistry Con
论文部分内容阅读
The importance of molecular diversity has been clearly recognized to identify specific bioactive small molecules for the elucidation of mysterious biological processes.The diversity-oriented synthesis (DOS) was introduced for efficient population of molecular diversity in untapped chemical space using complexity-generating synthetic route.To maximize the molecular diversity with high relevance in biological space, we pursued privileged-substructure-based DOS (pDOS) strategy to emphasize the importance of maximized skeletal diversity through the creative reconstruction of core skeletons containing privileged substructures.
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