【摘 要】
：
We report a new methodology for the synthesis of polymer-drug conjugates that are designed to self-assemble into nanoparticles and release drug in response to a physiologically relevant stimulus from
【机 构】
：
Institute of Molecular Medicine,State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer
【出 处】
：
第三届国际纳米药物大会 ChinaNanomedicine 2018 The 3rd International Con
论文部分内容阅读
We report a new methodology for the synthesis of polymer-drug conjugates that are designed to self-assemble into nanoparticles and release drug in response to a physiologically relevant stimulus from “compound”-all in one-prodrug monomers that consist of a cyclic polymerizable group that is appended to a drug through a cleavable linker.
其他文献
Autoimmune diseases such as inflammatory bowel diseases(IBD)causes reflactory chronic inflammation.Although stroid drugs are used in general,they causes sivere adverse effects and perfect cure is diff
Our recent studies demonstrated that NgBR is an essential gene for development because NgBR genetic depletion causes the early embryonic lethality.We utilized tissue-specific knockout approaches to fu
We have synthesized bovine serum albumin based BiNP for CT imaging but we find a temporary kidney injury by BiNP.Due to the previous reported risk of bismuth on human health,we extended our studies on
Silica nanoparticles(SiNPs)are widely applied in food sciences,industry and biomedicine,which greatly increase the human exposure and potential health risk.However,the effect of SiNPs on circulation s
As the largest biological filtration system in body,liver sequesters the majority of administered nanomedicines and causes low drug delivery efficiency to diseased tissue,which prevents the clinical t
Size and shape are fundamental properties of polymeric nanomedicine that determine its efficacy.Unlike size effect been well-studied,the impact of particle shape remains vaguely understood.1 In partic
Protein drugs are widely explored to prevent or treat chronic or inflammatory diseases and cancers because of their significant advantages in high specificity and function.However,therapeutic proteins
The development of multidrug resistance(MDR)in cancer remains one of the major causes for therapeutic treatment failure in clinic.Herein,mechanistic studies of a high-performing dual-drugs loaded poly
Polylactones like poly(L-lactide)(PLLA),poly(lactic-co-glycolic acid)(PLGA),poly(caprolactone)(PCL),and their PEG block derivatives,approved by the FDA for use,are the most popular biodegradable and b
The therapeutic performance of anti-cancer nanomedicine is greatly challenged by the low drug loading and tumor targeting.To overcome these issues,we first developed micelles with high drug loading an