Bilirubin-based copolymers self-assembled micelles with shape changeable ability and tumor targeting

来源 :第三届国际纳米药物大会 ChinaNanomedicine 2018 The 3rd International Con | 被引量 : 0次 | 上传用户:sanrenET
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  Herein,we reported a shape-changeable micelle composed of two kinds of triblock copolymers,BR-FFVLK-PEG and Ce6-FFVLK-PEG,which both included(i)functional hydrophobic block(bilirubin,BR or chlorin e6,Ce6),(ii)a phe-phe-val-leu-lys pentapeptide(FFVLK)derived from amyloid β(Aβ)and(iii)a hydrophilic polyethylene glycol(PEG,Mr = 790 Da)chain.
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