【摘 要】
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Objective:Now breast cancer still ranks the first in the women cancer incidence,and is also one of common cause of cancer-related death.The most frequent subtype of breast cancer is hormone receptor-p
【机 构】
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Department of Surgical Oncology, Second Affiliated Hospital,Zhejiang University School of Medicine,
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Objective:Now breast cancer still ranks the first in the women cancer incidence,and is also one of common cause of cancer-related death.The most frequent subtype of breast cancer is hormone receptor-positive subtypes,and premenopausal patient accounts for a large proportion.So a further of comprehensive breast cancer treatment for premenopausal patients has important clinical significance.Five years of tamoxifen(TAM) treatment is the cornerstone of current pre-menopausal hormone-receptor-positive breast cancer treatment.But there are some studies which have showed that in tamoxifen or aromatase inhibitors (AI) plus GnRHα induced ovarian suppression could produce more survival benefit.In these years,the st Gallen conference and ASCO guidelines have discussed GnRHα induced ovarian suppression for premenopausal breast cancer treatment.The main purpose of this study is to systematic evaluate the survival benefit of GnRHα induced ovarian suppression for premenopausal breast cancer patient,and to explore the optimal target population.In addition,using network meta-analysis,we can also evaluate the different drugcombination and course of treatment,and figure out the best drug combination of GnRHα induced ovarian suppression and the best course of treatment.
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