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Background: To evaluate the efficacy of routine ABP in LC for low-risk patients of the developing countries.Methods: We searched multiple databases for RCTs that compared the effects of perioperative ABP with placebo or no antibiotics on low-risk patients undergoing LC.Ten RCTs in developing countries were investigated by the meta-analysis.Results: The result suggested that the ABP group showed no significant reduction in overall infectious complications, superficial wound infectious complications, intra-abdominal infectious complications, distant infectious complications, positive bile bacteria cultures.However, prophylactic antibiotics prior to LC resulted in shorter length of hospital stay.Conclusions: Prophylactic antibiotic is unnecessary to use ABP for low-risk patients undergoing LC.