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目的 肿瘤细胞的生物学行为与其所处的微环境之间存在重要的关系。肿瘤细胞的快速增殖及肿瘤血管的异常，常常导致实体肿瘤中呈缺氧状态，以往我们认为缺氧主要影响肿瘤细胞的代谢和癌灶血管的重塑，但现在发现缺氧诱导因子在肿瘤的增殖、分化、侵袭转移产生重要的影响。
缺氧诱导因子1α(HIF-1α)调控Notch-1通路对胃癌生物学行为的影响及机制研究
【摘 要】
：
目的 肿瘤细胞的生物学行为与其所处的微环境之间存在重要的关系。肿瘤细胞的快速增殖及肿瘤血管的异常，常常导致实体肿瘤中呈缺氧状态，以往我们认为缺氧主要影响肿瘤细胞的代谢和癌灶血管的重塑，但现在发现缺氧诱导因子在肿瘤的增殖、分化、侵袭转移产生重要的影响。
【机 构】
：
中国医科大学附属第一医院
【出 处】
：
2019中国肿瘤学大会
【发表日期】
：
2019年7期
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