Modeling dorsal closure during Drosophila embryogenesis

来源 :2014 International Conference on Modeling of Complex Biologi | 被引量 : 0次 | 上传用户:as5881348
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  We report a mathematical model for the dynamic interaction among signaling proteins that control dorsal closure of the fruit fl Drosophila. Recent experiments have implicated the Par-family proteins as prominent players.In particular,aPKC suppresses the apicomedialactomyosin network,while Bazooka tends to inhibit aPKC.Their spatial recruitment from the cortex to the apicomedial surface introduces a delayed negative feedback loop.
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