Domino reactions have received attention and h used as powerful tools in modern organic synthesis for the synthetically efficient construction of various heterocyclic molecules in one sequence without the isolation of intermediates.The development of new domino processes that construct highly functionalized polysubstituted organic compounds from easily available starting materials is an important goal of synthetic chemistry and also represents a continuing challenge.Functionalized furans and imidazo[1,2-a]pyridines are extremely useful molecules which exhibit a wide range of biological activities1 and appear as key structural units in many important pharmaceuticals,natural products,and various materials.The development of efficient ways to construct those compounds from readily available starting materials under mild conditions continues to attract the interest of organic chemists due to their remarkable application value.Herein,we have described a series of domino reaction for the construction of furans and imidazo[1,2-a]pyridines from ynals.