目的 制备一种新型的载ICG和RGD肽的靶向相变光声造影剂,检测其靶向性。方法 用双乳化法合成载ICG的相变造影剂,然后与RGD肽通过MAL-SH键连接。通过将造影剂与MB-231细胞在体外共孵育来检测其靶向性。结果 在激光共聚焦显微镜下,RGD-PLGA发红光。体外实验证实,在荧光显微镜下,RGD-PLGA与MB-231细胞紧密连接。流式细胞术也显示RGD-P LGA与MB231细胞有很高的连接
目的 制备相变型链霉亲和素化乳酸/羟基乙酸共聚物(PLGA)纳米粒(PLGA-SA/P FP)，探讨其运用预定位技术通过平行板流动腔靶向肿瘤细胞的能力，以评价预定位技术在超声分子成像领域中的应用前景。
目的 制作粒径均一稳定的脂质纳米气泡,通过偶联携带有HER2分子配体的超微小分子Affibody,合成能靶向肿瘤HER2分子的超声造影剂"纳米气泡-Affibody" 复合物,并通过体内、体外实验验证其对肿瘤的分子靶向性及超声造影效果。
女性患者,66岁,体检发现左侧肾上腺区占位6月.超声检查(图1、2)示:左侧肾上腺区域见一个大小约3.7cm×3.2cm的肿块图像,形状呈椭圆形,边界清楚,内部呈密集的强回声,后方回声无变化,彩色多普勒显示:肿块内未见明显血流信号.左侧肾上腺区域实质性占位病变,性质待查,考虑来源于肾上腺,脂肪瘤可能.CT示:左侧肾上腺内外侧支分叉处混合密度肿块,大小约3.0cm×2.6cm,界清,其内脂肪密度与软
目的 报告经手术与病理最后确诊的57例输尿管狭窄疾病的超声检查结果，旨在研究不同输尿管狭窄位置和病因与肾积水输尿管扩张程度的关系，探讨超声检查对输尿管狭窄的定位与定性诊断价值。方法 对57例(59侧)经超声显像诊断并由手术与病理证实的输尿管狭窄进行回顾性分析。
Objective Hemoptysis or severe hemoptysis may be fatal in the absence of appropriate, adequate and prompt management before etiological diagnosis.The most important problem in treatment of the conditi
Objective Interleukin-17A (IL-17) is known to play important roles in immune and inflammatory responses as occur in asthma, but its functions in inflammation of the allergic airway are still controver
Objective Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for sampling intrathorocic lymph nodes has become standard of care in diagnosing malignant and benign lymph nodes
Objective Acute exacerbations of COPD (AECOPD) are important events during disease procedure.Previous studies have demonstrated the significant association between outdoor air pollution and AECOPD hos
Objective The aim of this study was to evaluate the value of noninvasive ventilation (NIV) following early extubation in very elderly patients with Severe community-acquired pneumonia (SCAP).