AIM Cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication.Thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment.In the present study, the effect of Khamira Marwarid Abdul Hameed (KAH1) , a unani formulation known to possess cognitive-enhancing and antistress property, was evaluated on the course of pentylenetetrazole induced seizures, learning deficit and oxidative stress markers in mice.METHODS Male albino mice were injected PTZ (65 mg·kg-1, sc) on the 5th day of the treatment for the development of seizures.Spontaneous alternation behaviour was carried out on the 1st and the 5th day of the treatment after PTZ administration, while the oxidative stress parameters (maiondialdehyde and glutathione) were carried out in the whole brain upon the completion of the behavioural assessment.RESULTS The administration of KAH1 (50 mg·kg-1) decreased the PTZ induced seizures and showed improvement in the learning deficit induced by PTZ as evidenced by the increased latency time and frequency of jerks and improvement in SAB.CONCLUSION The findings suggest the potential of KAH1 as adjuvant to antiepileptic drugs with an added advantage of preventing cognitive impairment.