Alzheimers disease(AD)is associated with the aggregation of the amyloid-beta(Aβ)peptides into toxic aggregates.How to inhibit the aggregation of Aβ peptides has been extensively studied over recent decades.The methods for eliminating the formed fibrils,however,have been reported rarely.Here,gold nanorods(Au NRs)are attempted for the destruction of formed mature Aβ fibrils under the irradiation of near infrared femtosecond(fs)laser(～800 nm).