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A 56-year-old male patient was referred to hospital because of space-occupying lesion in right upper lobe of lung.The chest computed tomography(CT) scan showed that there was a 4.4*5.6 cm mass in the right upper lobe of lung.When doctors performed the physical examination,they found his right supraclavicular lymph node enlargement, PET-CT showed the SUV of it was 5.57,indicated it maybe metastasis of cancer.It seemed to be a stage ⅢB(cT2bN3M0) lung cancer.In order to confirm the accurate stage,doctors performed needle aspiration biopsy of lymph node,but they did not find tumor cell in the lymph node.Then doctors performed the lymphadenectomy on the patient,the final pathological result was Castleman Disease.After the lobectomy and complete mediastinal and hilar lymphadenectomy,the final pathological stage of this patient was Stage ⅡA(pT2bN0M0) lung cancer.We believe this is the first described case of lung cancer with Casterman's Disease in supraclavicular lymph node, and we emphasize that for every patient of malignant tumor, accurate diagnosis and stage is the most important factor in the therapeutic process.