Most chromatographic methods offer quantitative analysis capabilities.Similarly, comprehensive twodimensional gas chromatography (GC × GC) should provide the ability to measure components over a definable range of concentrations, according to the limits of detection and upper ranges of applicability of the method.However, response measurement in a quantitative sense is different for GC × GC compared with one-dimensional methods.The modulation peak pulses for each compound, means the sum of these should contain the required quantitative metric.Both total peak area and total peak height should be available from the modulated experiment.The presentation of the GC × GC result as contour or colour plot also suggests we might interpret the total response in terms of the peak volume.Any method that considers summing the individual pulsed peaks must make some decision on how many of the second dimension peaks to sum, and how they are to be identified.Clearly, a Gaussian peak has a given definable standard deviation, and width at base, but the limits of the distribution in the time domain are not so well established.The decision of how many peaks to sum is not well defined.Asymmetrical peaks will lead to more observable peaks, and also there may be residual overlap of peaks, even in the higher resolution GC × GC method, that will demand accurate peak deconvolution.