Background: To investigate the role of TRPV1 in the pathological process of DO induced by partial bladder outlet obstruction (pBOO).Methods: In 40 female Wistar rats,pBOO was achieved by partial urethral ligation and urodynamic analysis was taken to filter the DO rats six weeks later.Urinary bladder and dorsal root ganglia (DRG) were removed and RT-PCR,Western Blot and IHC were performed to investigate the expression and location of TRPV1 in control and DO rats.