论文部分内容阅读
Defective coupling between sarcoplasmic reticulum (SR) and mitochondria for control of intracellular Ca2+ signaling has been implicated in several neuromuscular diseases.Our previous study showed that skeletal muscle derived from an amyotrophic lateral sclerosis (ALS)mouse model (G93A) display segmental loss of mitochondrial function that was coupled with augmented SR Ca2+ release activity.