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Systemic inflammatory response triggered by majorsurgery,trauma,bums and ischemia-reperfusion cancause organ mjury and lead to a higher morbidity andmortality peri-operatively,which has become thepivotal challenges foranesthesiologists.Understanding the pathways andmechanisms of inflammationwill translate into widespread benefit for basicresearch and clinical trial,promote bench tobedside,andimprove the outcome of patients.Here,the pathway ofimmune & inflammation and their relation to organinjury ale overviewed.