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Object To investigate the role of autophagy and heparinbinding hemagglutinin(HBHA)protein of M.tuberculosis in the internalization procedure.IMethods The necrosis of A549 was analyzed through LDH measurement,and autophagy was determined by LC3 level in western blot and confocal microscopy.Then a recombinant Mycobacterium smegmatis expressed HBHA(rMS-HBHA)was created to check the role of HBHA in its infection.