Biological Evaluation of Brominated Chalcone Derivative

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:yudsly2002
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Chalcone,which exist in the Kava plant[1] aroused considerable interest recently for their various bioactivities,including anti-inflammatory,anti-microbial and especially anti-cancer activities[2].
其他文献
Quinazoline have been recognized as important heterocyclic compounds due to their diverse biological activities such as antihypertensive,antimicrobial,antihyperlipidemic,antiinflammatory and anticonvu
肿瘤一直是威胁人类健康的常见病和多发病,人类因肿瘤而引起的死亡率也在逐年增加,核苷类药物仍然是一类重要的抗肿瘤药物,同时三氮唑化合物类也有良好的抗肿瘤活性[1],因此,该课题组在以前期发现的具有三环结构双异头碳的新型C10 高碳糖的基础上[2],对其进行衍生化拟合成一些新型的三氮唑取代高碳糖核苷类似物,为其进行生物活性研究筛选和评价,以期发现具有较好活性的抗肿瘤类药物。
It is well known that the tetracyclic diterpenoids related with Rabdosia Rubescens emerge good activities against a variety of tumor cell lines[1,2].
会议
As the first identified histone demethylase,Lysine specific demethylase 1(LSD1)plays an important role in epigenetic regulation of gene activation and repression.
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China Five and six membered aza-heterocyclic systems are scaffolds of many efficacious drugs.
5,6-二氢-6-烷基-2-吡喃酮代表了一大类的生物活性有机分子。比如:Pironetin[1-3],(-)Butungolide,CytostatinRasfonin,Callystatin A,Fostriecin,以及Phoslactormycin B 等均表现出了良好的抗肿瘤活性。
LSD1(also known as KDM1A)is the first identified histone lysine demethylase.It converts mono-or di-methylated histone H3(H3K4me1/me2)to unmodified H3[1].
Lysine specific demethylase 1(LSD1),the first identified histone lysine demethylase by Yang Shi group in 2004[1],specifically catalyzes demethylation of mono-and di-methylated lysine 4 and lysine 9 of
The p53 tumor suppressor protein plays a key role in regulation of several important cellular processes,including cell cycle,apoptosis,DNA repair and angiogenesis.