Solid dispersion is an effective method to improve the solubility and dissolution rate of insoluble drugs.The role of solid dispersion to improve drug dissolution rate is mainly dependent on the properties of the carrier materials,which plays an important role in inhibiting the precipitation of crystals and maintaining the stability of the dissolution process.Therefore,the selection of carrier materials is essential for the preparation of the best dispersion of drug and the stability of the solid dispersion.In this study,lacidipine was chosen as the model drug and solvent-shift method was used to screen the precipitation inhibitors of lacidipine supersaturation system.The selected polymers Soluplus,HPMC E5,and PVP K30 were applied to make preparation of solid dispersions by solvent evaporation method.The three amorphous solid dispersions(ASDs) were then characterized by polarization microscope,differential scanning calorimetry,powder X-ray diffraction,fourier transform infrared spectroscopy(FT-IR) and dissolution test.Finally,the physical stability of ASDs was preliminarily studied under high temperature and high humidity conditions.The results showed that the apparent rank order of polymers for superaturation enhancement was Soluplus > HPMC E5 > PVP K30 ≈ VA 64 ≈ F68.FT-IR indicated that hydrogen bond was formed in the successfully prepared ASDs.The dissolution results showed that the ASDs had similar dissolution behavior with commercial tablet LACIPIL in 0.07%Tween 80 media,while the dissolution-precipitation results in water were in line with the polymer rank order above.From the physical stability study,Soluplus ASD could be stable under these conditions.There was no crystallization detected within 10 d,and the hydrogen bond between lacidipine and Soluplus was not disrupted.PVP K30 ASD was the most hygroscopic and its stability was the worst.The hydrogen bond between drug and PVP K30 was disrupted,and there were a lot of crystal generated under high humidity.HPMC E5 ASD had a similar situation to PVP K30 ASD,but it was more stable than PVP K30 ASD.The findings showed that high hygroscopicity is the main cause for the poor system stability of PVP K30 ASD,while drug-polymer interaction serves as the determinant of the stability of Soluplus and HPMC E5 ASDs.In conclusion,solvent-shift method was successfully applied to screening the carrier materials,and provided a high throughput screening platform for the formulation of solid dispersion.