Objective:The aim of this study was to assess the potential of vinpocetine loaded micelles fabricated from mPEG-PLA as a sustained release system and its pharmacokinetics in rats.Methods:Three micelle fabrication methods were examined to maximize vinpocetine loading,followed by structurally characterized and investigation of in vitro release and in vivo pharmacokinetics in Sprague-Dawley rats.Plasma pharmacokinetic parameters of vinpocetine in micelle formulation were compared to its clinical formulation.