【摘 要】
：
The early diagnosis of diabetes mellitus, one of the top 3 chronic incurable diseases, is becoming increasingly important.Here, we investigated the applicab
【机 构】
：
SchoolofLifeScience,BeijingInstituteofTechnology,China
【出 处】
：
中国化学会首届全国质谱分析学术研讨会
论文部分内容阅读
The early diagnosis of diabetes mellitus, one of the top 3 chronic incurable diseases, is becoming increasingly important.Here, we investigated the applicability of an 18O-labeling technique for the development of a standard-free, label-free LC-MS/MS method for the early diagnosis of type 2 diabetes mellitus.Rather than attempting to identify quantitative differences in proteins as biomarkers, glycation of the highest abundance protein in human plasma, human serum albumin (HSA), was monitored through quantitative analysis of HSA characteristic peptides using the 18O-labeling technique.
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