Chronic stress is broadly used to model anxiety and depression.However,in chronic stress models,anxiety and depressive-like behaviors might be masked by unspecific effects of stress.
Emerging evidence indicates that metabotropic glutamate receptor 5(mGluR5)critically modulates drug and drug related behaviors.However,the role of mGluR5 in the opiate-induced contextual memory remain
Objective During the early postnatal period,environmental influences play a pivotal role in shaping the development of the neocortex,including the prefrontal cortex(PFC)that is crucial for working mem
Background: Electroconvulsive therapy(ECT)is an important treatment option for depression in clinical practice.Compared to antidepressant drugs,ECT has a more rapid onset and is also effective for tre
Nowadays,there are still many arguments on the impact of depression on pain sensory.Our previous study improved that depression attenuate allodynia of rats with chronic pain,but the certain neural mac
Auditory verbal hallucination(AVH) is one of the most representative and potentially debilitating symptoms of schizophrenia.Its exact pathophysiology and underlying neurobiology still remain elusive.
Accumulating evidence indicated that N-methyl-D-aspartate(NMDA)receptors are involved in the pathophysiology of depression and implicated in therapeutic targets.
Objective: Neuroimaging studies show that patients with major depression have reduced volume of the orbitofrontal cortex(OFC).Although the serotonin(5-HT)2A receptor,which is abundant in the OFC,has b