【摘 要】
:
Background Here we were to assess the possible associations between variations in CCL5, CCL2, CCR5, and CCR2genes and susceptibility to myocardial infarction (MI) in a case-control study.Methods Genot
【机 构】
:
Second Affiliated Hospital,School of Medicine,Zhejiang University
论文部分内容阅读
Background Here we were to assess the possible associations between variations in CCL5, CCL2, CCR5, and CCR2genes and susceptibility to myocardial infarction (MI) in a case-control study.Methods Genotypes of patients with MI (n=634) were compared to controls (n=601).The CCL5 rs2107538 (-403G>A),CCL2 rs1024611 (-2518A>G), CCR5 rs333 (A32 ins>del), and CCR2 rs1799864 (190G>A) gene polymorphisms were evaluated in 1235 individuals by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)mapping.Results No subject was found for CCR5-A32 allele in present study.No association was established between CCL2rs1024611 and CCR2 rs1799864 polymorphisms and MI.Concerning CCL5 rs2107538 polymorphism, the A allele occurred at a higher frequency in patients with MI than in control subjects.Furthermore, the A/A genotype of CCL5rs2107538 associated with a significantly increased risk of MI, independently of conventional cardiovascular risk factors(OR =3.346, 95% CI =1.938-5.775, P <0.001, A/A vs.G/G).Further analysis showed that MI patients had significantly more A-403-A-2518 haplotype (CCL5-403G>A/CCL2-2518A>G, 21.8% vs.26.6%, OR=1.230, 95%CI=1.012-1.493,P=0.038) and AA/AA genotype (CCL5-403G>A / CCL2-2518A>G, 5.0% vs.12.1%, OR=3.245, 95%CI=1.780-5.914,P<0.001).Conclusions Although the data do not support an association between CCL2 rs1024611, CCR2 rs1799864 and CCR5rs333 polymorphisms and MI, the genetic variation in CCL5 gene may be a useful genetic marker for determining susceptibility to MI in the Chinese Han population.
其他文献
Background To study therapeutic efficacy and safety of high dose clopidogrel in patients with coronary heart diseases(CHD) who underwent selective pereutaneous coronary intervention (PCI).Methods A to
Background To evaluate the early diagnostic value of matrix metalloproteinase-9 (MMP-9) level on admission for ST-segment elevation myocardial infarction (STEMI), explore the relationship between MMP-
Background Explore intravascular ultrasound to unprotected left main coronary artery disease drug-eluting stents interventional treatment for the guiding role and the influence of for prognosis, explo
Background To investigate the changes of matrix rnetalloproteinase-9 (MMP-9) concentration in patients with ST-segment elevation myocardial infarction (STEMI) and to evaluate its clinical significance
Background The interventional treatment of chronic total occlusions (CTO) is one of the major challenges in contemporary interventional cardiology.The CTO cases are identified in 15%-30% of all patien
Background Fully absorbable stents may have positive effects on arterial healing, and reduce the need for prolonged antiplatelet therapy.This study aimed to test the safety and efficacy of a novel ful
Background This study sought to investigate the effects of rhBNP on L-type calcium current (ICa-L) in left ventricular myocytes of rabbit heart undergoing ischemia-reperfusion, so as to explore the ce
Background To investigate the long term effect of both thrombus aspiration catheter and tirofiban therapy on patients with ST-segment elevatuion acute myocardial infarction (AMI).Methods From Jun 2006
Background Primary percutaneous coronary intervention (PCI) is now considered the optimal approach to management of ST-segment elevation myocardial infarction.Since, diabetes were established risk fac
Background To investigate whether insufficient myocardial reperfusion plays an important role in left ventricular (LV)remodeling and on the prognosis for functional recovery in patients with TIMI flow