【摘 要】
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Background Here we were to assess the possible associations between variations in CCL5, CCL2, CCR5, and CCR2genes and susceptibility to myocardial infarction (MI) in a case-control study.Methods Genot
【机 构】
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Second Affiliated Hospital,School of Medicine,Zhejiang University
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Background Here we were to assess the possible associations between variations in CCL5, CCL2, CCR5, and CCR2genes and susceptibility to myocardial infarction (MI) in a case-control study.Methods Genotypes of patients with MI (n=634) were compared to controls (n=601).The CCL5 rs2107538 (-403G＞A),CCL2 rs1024611 (-2518A＞G), CCR5 rs333 (A32 ins＞del), and CCR2 rs1799864 (190G＞A) gene polymorphisms were evaluated in 1235 individuals by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)mapping.Results No subject was found for CCR5-A32 allele in present study.No association was established between CCL2rs1024611 and CCR2 rs1799864 polymorphisms and MI.Concerning CCL5 rs2107538 polymorphism, the A allele occurred at a higher frequency in patients with MI than in control subjects.Furthermore, the A/A genotype of CCL5rs2107538 associated with a significantly increased risk of MI, independently of conventional cardiovascular risk factors(OR =3.346, 95％ CI =1.938-5.775, P ＜0.001, A/A vs.G/G).Further analysis showed that MI patients had significantly more A-403-A-2518 haplotype (CCL5-403G＞A/CCL2-2518A＞G, 21.8％ vs.26.6％, OR=1.230, 95％CI=1.012-1.493,P=0.038) and AA/AA genotype (CCL5-403G＞A / CCL2-2518A＞G, 5.0％ vs.12.1％, OR=3.245, 95％CI=1.780-5.914,P＜0.001).Conclusions Although the data do not support an association between CCL2 rs1024611, CCR2 rs1799864 and CCR5rs333 polymorphisms and MI, the genetic variation in CCL5 gene may be a useful genetic marker for determining susceptibility to MI in the Chinese Han population.
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