Leukemogenic effects of Ptpn11(Shp2)activating mutations in the stem cell microenvironment

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：wujie365

【摘要】

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【作者】

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Cheng-Kui Qu

【机构】

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Department of Pediatrics,Division of Hematology/Oncology,Aflac Cancer and Blood DisordersCenter,Chil

【出处】

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2016年国际生理学学术大会

【发表日期】

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2016年6期

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　　Germline activating mutations of protein tyrosine phosphatase PTPN11(Shp2),a positive regulator of the Ras signaling pathway,are associated with 50%of patients with Noonan syndrome.These patients have an increased risk of developing leukemias,especially juvenile myelomonocytic leukemia(JMML),a childhood myeloproliferative neoplasm(MPN).

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Leukemogenic effects of Ptpn11(Shp2)activating mutations in the stem cell microenvironment

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