【摘 要】
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Due to its programmability and predictability,DNA nanomachine shows remarkable specificity and versatility in molecular recognition.Thus,DNA nanomachine has recently attracted great attention in detec
【机 构】
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Cancer Metastasis Alert and Prevention Center,Fujian Provincial Key Laboratory of Cancer Metastasis
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Due to its programmability and predictability,DNA nanomachine shows remarkable specificity and versatility in molecular recognition.Thus,DNA nanomachine has recently attracted great attention in detecting DNA,microRNA,small molecules and proteins.In the current contribution,we propose a DNA nanomachine(simplified as MB-PP)by inserting molecular beacon into a padlock probe,which can be used for the sensitive and specific detection of the codon 12 of K-ras gene.In the presence of target DNA,MB-PP is able to be cyclized by ligase because its two ends are pulled together by target species.
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