Recent studies have established that histone deacetylase 6(HDAC6)is associated with oncology,immune-inflammatory and neurodegenerative disorders.[1] Besides,selective histone deacetylase 6 inhibitors
Histone lysine-specific demethylase 1(LSD1)is an FAD-dependent demethylase that catalyzes the removal of methyl groups from lysine-4 in histone H3,thereby mediating gene repression[1].
Chemical modification,consisting of phosphorodithioate(PS2)and 2-O-Methyl(2-OMe)MePS2 on one nucleotide that significantly enhances potency and resistance to degradation for various siRNAs.
Benzimidazole moiety is a structural isostere of naturally occurring nucleotides and it has been extensively utilized as a drug scaffold in the medicinal chemistry.
Histone lysine specific demethylase 1(LSD1)is the first identified histone demethylase,which can demethylate mono-and di-methylated histon3 lysine 4(H3K41/2)and histone 3 lysine 9(H3K9me1/2)when it is