Aqueous extracts from fruit bodies and submerged mycelia of various higher Basidiomycetes were studied in search for reliable biological effects.In vitro and in vivo experiments were conducted.The results showed that the aqueous extracts demonstrated various types of marked biological actions:an increased production of reactive oxygen forms by neutrophil cells of human peripheral blood; a significant mitogenic activity in a wide range of concentrations;stimulation on production of inflammatory cytokines; a decrease in both average tumor size in mice with transplanted melanoma B 16 and a manifestation of tumorous intoxication;and a prolongation in the survival rate of such mice.Addition of studied extracts to daily fodder was increasing immunological status of tested animals.Thus such extracts can be used to fortify various types of meals.