【摘 要】
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Many current theories of Parkinson s disease (PD) suggest that inflammation is involved in the neurodegenemtive process.Tripchlorolide (TW397),a traditional Chinese herbal compound with anti-inflammat
【机 构】
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Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiaotong
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Many current theories of Parkinson s disease (PD) suggest that inflammation is involved in the neurodegenemtive process.Tripchlorolide (TW397),a traditional Chinese herbal compound with anti-inflammatory and immunosuppressive properties,has been shown to protect and restore dopaminergic neurons against the neurotoxicity induced by 1-methyl-4-phenylpyridinium ion in vitro.This study was designed to investigate TW397s effect in vivo in the PD model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned C57BL/6 mice.In the present study,the neurotoxin MPTP reduced the survival ratio of tyrosine hydroxylase-immunoreactive (TH-IR) neurons in the substantia nigra pars compacta and TH-IR fibers in striatum to 65% and 12% of the normal control,respectively.Intriguingly,treatment with TW397 of 1 μg/kg for 16 days once per day dramatically improved the survival rate of TH-IR neurons in the substantia nigra pars compacta and TH-IR fibers in striatum to 82% and 38% of the control,meanwhile,significantly improved the level of dopamine in the substantia nigra and striatum to 157% and 191% of the vehicle-treated group,respectively.In addition,the Rota-Rod performance of the animals treated with 0.5 μg/kg or 1 μg/kg TW397 were significantly improved for about 2 or 3 fold relative to vehicle-treated animals,respectively.These data demonstrate a neuroprotective action of TW397 in vivo against MPTP toxicity,which has important implications for the treatment of PD.
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