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High IGF-1, IGFBP-3, testosterone and 16aphaOHE levels increase early breast cancer.We studied the joint effects of OC use, parity, coffee and polymorphisms on hormones and breast volumes in young healthy women from highrisk breast cancer families and in sporadic breast cancer patients.Questionnaires were collected.Body measurements and blood samples were obtained in healthy women and pre-and post-operatively in patients.