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Purpose To investigate the feasibility of low tube voltage indirect CT venography(CTV)with iterative reconstruction(IR)in superficial venous system in varicose veins(VV)of lower limbs.Materials and Methods This prospective study has been approved by the hospital institutional review board.Fifty-five consecutively patients(F/M,23/32,age range 15-77 years)suspicious of varicose veins were recruited in this study.All the patients were performed CT venography(CTV)in lower limbs.The signal intensity(SI)of great saphenous vein(GSV)and varicose vein(VV)was measured,and the signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)were calculated.Subjective image quality of MPR and 3D volume rendering(VR)were blindly assessed by two experienced radiologists using a 3-point scale.