Ribosomes, the universal cellular machines, possess spectacular architecture accompanied by inherent mobility, allowing for their smooth performance as polymerases that translate the genetic code into proteins.The site for peptide bond formation is located at the ribosome core within a universally conserved symmetrical region.The high conservation of this region implies its existence irrespective of environmental conditions and indicates that it may represent a prebiotic RNA entity with catalytic capabilities.This region alongside other functional sites, are targeted by various antibiotics.Attempts at improving these antibiotics, at designing novel therapeutics and combating antibiotics resistance, are in progress.