【摘 要】
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King cobra (Ophiophagus hannah) is widely distributed and divergent throughout Asia.To elucidate the venom complexity of Malaysian species (MOH),venom gland was extracted from a 190-cm MOH (central-we
【机 构】
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Department of Pharmacology,Faculty of Medicine,University of Malaya,Kuala Lumpur,Malaysia
【出 处】
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10th IST Asia Pacific Congress on Animal , Plant and Microbi
论文部分内容阅读
King cobra (Ophiophagus hannah) is widely distributed and divergent throughout Asia.To elucidate the venom complexity of Malaysian species (MOH),venom gland was extracted from a 190-cm MOH (central-west Peninsula),4 days post-venom milking.Venom-gland transcriptome was investigated with Illumina HiSeqTM platform;proteome was profiled using in-gel-nano-ESI-LCMS/MS.Transcriptomic result reveals high redundancy of toxin transcripts (3578.82 FPKM/transcript) despite small cluster number,implying gene duplication of restricted protein families in the accelerated MOH-venom evolution.
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